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Abstract
AIMS
To elucidate the influence of the time-intervals between the onset and arrival (TIME 1), onset and delivery (TIME 2), and the decision to deliver and delivery (TIME 3) on severe adverse outcomes of offspring born to mothers complicated by placental abruption outside the hospital.
METHODS
This is a multicenter nested case-control study about placental abruption at f*ckui Prefecture, a regional area in Japan, through 2013 to 2017. Multiple pregnancy, fetal or neonatal congenital abnormality, and unknown detailed information at onset of placental abruption were excluded. A composite of perinatal death and cerebral palsy or death at 18-36 months of corrected age was defined as the adverse outcome. The relationship between time-intervals and the adverse outcome was analyzed.
RESULTS
The 45 subjects for analysis were divided into two groups, including a group with and without adverse outcome (poor, n = 8; and good, n = 37). TIME 1 was longer in the poor group (150 vs. 45 min, p < 0.001). A subgroup analysis targeted to 29 cases with preterm birth at the third trimester indicates that TIME 1 and TIME 2 were longer in the poor group (185 vs. 55 min, p = 0.02; and 211 vs. 125 min, p = 0.03), while TIME 3 was shorter in the poor group (21 vs. 53 min, p = 0.01).
CONCLUSIONS
Long time-intervals between onset and arrival or onset and delivery may be correlated with perinatal death or cerebral palsy in surviving infants affected by placental abruption.
Authors+Show Affiliations
Department of Obstetrics and Gynecology, University of f*ckui, f*ckui, Japan.
Department of Obstetrics and Gynecology, University of f*ckui, f*ckui, Japan.
Department of Obstetrics and Gynecology, University of f*ckui, f*ckui, Japan.
Department of Obstetrics and Gynecology, University of f*ckui, f*ckui, Japan.
Department of Obstetrics and Gynecology, University of f*ckui, f*ckui, Japan.
Department of Obstetrics and Gynecology, University of f*ckui, f*ckui, Japan.
MeSH
InfantPregnancyInfant, NewbornFemaleHumansAbruptio PlacentaeCase-Control StudiesPerinatal DeathJapanCerebral PalsyPremature BirthRetrospective StudiesPlacentaHospitalsPregnancy Outcome
Pub Type(s)
Multicenter Study
Journal Article
Language
eng
PubMed ID
36808792
Citation
Kawamura, Hiroshi, et al. "Impact of Maternal Late Hospital Arrival On Adverse Outcome of Offspring Affected By Placental Abruption: a Regional Multicenter Nested Case-control Study in Japan." The Journal of Obstetrics and Gynaecology Research, vol. 49, no. 5, 2023, pp. 1341-1347.
Kawamura H, Takahashi N, Miyazaki Y, et al. Impact of maternal late hospital arrival on adverse outcome of offspring affected by placental abruption: A regional multicenter nested case-control study in Japan. J Obstet Gynaecol Res. 2023;49(5):1341-1347.
Kawamura, H., Takahashi, N., Miyazaki, Y., Tsuyoshi, H., Orisaka, M., & Yoshida, Y. (2023). Impact of maternal late hospital arrival on adverse outcome of offspring affected by placental abruption: A regional multicenter nested case-control study in Japan. The Journal of Obstetrics and Gynaecology Research, 49(5), 1341-1347. https://doi.org/10.1111/jog.15579
Kawamura H, et al. Impact of Maternal Late Hospital Arrival On Adverse Outcome of Offspring Affected By Placental Abruption: a Regional Multicenter Nested Case-control Study in Japan. J Obstet Gynaecol Res. 2023;49(5):1341-1347. PubMed PMID: 36808792.
* Article titles in AMA citation format should be in sentence-case
TY - JOURT1 - Impact of maternal late hospital arrival on adverse outcome of offspring affected by placental abruption: A regional multicenter nested case-control study in Japan.AU - Kawamura,Hiroshi,AU - Takahashi,Nozomu,AU - Miyazaki,Yumiko,AU - Tsuyoshi,Hideaki,AU - Orisaka,Makoto,AU - Yoshida,Yoshio,Y1 - 2023/02/18/PY - 2022/11/19/receivedPY - 2023/01/28/acceptedPY - 2023/5/3/medlinePY - 2023/2/23/pubmedPY - 2023/2/22/entrezKW - arrivalKW - cerebral palsyKW - onsetKW - perinatal deathKW - placental abruptionSP - 1341EP - 1347JF - The journal of obstetrics and gynaecology researchJO - J Obstet Gynaecol ResVL - 49IS - 5N2 - AIMS: To elucidate the influence of the time-intervals between the onset and arrival (TIME 1), onset and delivery (TIME 2), and the decision to deliver and delivery (TIME 3) on severe adverse outcomes of offspring born to mothers complicated by placental abruption outside the hospital. METHODS: This is a multicenter nested case-control study about placental abruption at f*ckui Prefecture, a regional area in Japan, through 2013 to 2017. Multiple pregnancy, fetal or neonatal congenital abnormality, and unknown detailed information at onset of placental abruption were excluded. A composite of perinatal death and cerebral palsy or death at 18-36 months of corrected age was defined as the adverse outcome. The relationship between time-intervals and the adverse outcome was analyzed. RESULTS: The 45 subjects for analysis were divided into two groups, including a group with and without adverse outcome (poor, n = 8; and good, n = 37). TIME 1 was longer in the poor group (150 vs. 45 min, p < 0.001). A subgroup analysis targeted to 29 cases with preterm birth at the third trimester indicates that TIME 1 and TIME 2 were longer in the poor group (185 vs. 55 min, p = 0.02; and 211 vs. 125 min, p = 0.03), while TIME 3 was shorter in the poor group (21 vs. 53 min, p = 0.01). CONCLUSIONS: Long time-intervals between onset and arrival or onset and delivery may be correlated with perinatal death or cerebral palsy in surviving infants affected by placental abruption. SN - 1447-0756UR - https://www.unboundmedicine.com/medline/citation/36808792/Impact_of_maternal_late_hospital_arrival_on_adverse_outcome_of_offspring_affected_by_placental_abruption:_A_regional_multicenter_nested_case_control_study_in_Japan_DB - PRIMEDP - Unbound MedicineER -
